Pub. Date : 2017 May 2
PMID : 28415819
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aspirin regulation of c-myc and cyclinD1 proteins to overcome tamoxifen resistance in estrogen receptor-positive breast cancer cells. | Aspirin | cyclin D1 | Homo sapiens |
| 2 | Aspirin combined with tamoxifen can down regulate cyclinD1 and block cell cycle in G0/G1 phase. | Aspirin | cyclin D1 | Homo sapiens |
| 3 | When knocking down c-myc in MCF-7/TAM, cells become more sensitive to tamoxifen, cell cycle is blocked as well, indicating that aspirin can regulate c-myc and cyclinD1 proteins to overcome tamoxifen resistance. | Aspirin | cyclin D1 | Homo sapiens |