Pub. Date : 2017 Jun 24
PMID : 28412356
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1). | leptomycin B | exportin 1 | Homo sapiens |
| 2 | Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1). | leptomycin B | exportin 1 | Homo sapiens |
| 3 | Leptomycin B (LMB), the first specific inhibitor of CRM1 identified, binds covalently to cysteine 528 in the nuclear export signal binding region of CRM1 leading to the inhibition of protein nuclear export. | leptomycin B | exportin 1 | Homo sapiens |
| 4 | Leptomycin B (LMB), the first specific inhibitor of CRM1 identified, binds covalently to cysteine 528 in the nuclear export signal binding region of CRM1 leading to the inhibition of protein nuclear export. | leptomycin B | exportin 1 | Homo sapiens |
| 5 | Leptomycin B (LMB), the first specific inhibitor of CRM1 identified, binds covalently to cysteine 528 in the nuclear export signal binding region of CRM1 leading to the inhibition of protein nuclear export. | leptomycin B | exportin 1 | Homo sapiens |
| 6 | Leptomycin B (LMB), the first specific inhibitor of CRM1 identified, binds covalently to cysteine 528 in the nuclear export signal binding region of CRM1 leading to the inhibition of protein nuclear export. | leptomycin B | exportin 1 | Homo sapiens |
| 7 | Although the biochemical mechanisms of action of CRM1 inhibitors such as LMB are well studied, the subcellular effects of inhibition on CRM1 are unknown. | leptomycin B | exportin 1 | Homo sapiens |
| 8 | GFP-tagged CRM1 protein microinjected into the cytoplasm of A549 cells distributed throughout the cell in untreated cells remained primarily cytoplasmic in LMB-treated cells. | leptomycin B | exportin 1 | Homo sapiens |
| 9 | Upon nuclear microinjection, GFP-CRM1 translocated to and accumulated in the cytoplasm of LMB-treated cells. | leptomycin B | exportin 1 | Homo sapiens |