Title : Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3β/β-catenin integrated signaling pathway.

Pub. Date : 2017 Jul 15

PMID : 28408345






3 Functional Relationships(s)
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1 Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3beta/beta-catenin integrated signaling pathway. icariin thymoma viral proto-oncogene 1 Mus musculus
2 Interestingly, DKK1, an inhibitor of Wnt/beta-catenin signaling inhibitor, and LY294002, an inhibitor of PI3K/Akt signaling, abolished the induction of DEC1 by icariin. icariin thymoma viral proto-oncogene 1 Mus musculus
3 Taken together, it is concluded that DEC1 likely supports the action of icariin against glucocorticoid induced osteoporosis with an involvement of the PI3K/Akt/GSK3beta/beta-catenin integrated signaling pathway. icariin thymoma viral proto-oncogene 1 Mus musculus