Pub. Date : 2017 May 23
PMID : 28404960
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Impact of metformin on C-reactive protein levels in women with polycystic ovary syndrome: a meta-analysis. | Metformin | C-reactive protein | Homo sapiens |
| 2 | The impact of the recommended first-line treatment with metformin on C-reactive protein (CRP) levels in patients with polycystic ovary syndrome (PCOS) is still controversial. | Metformin | C-reactive protein | Homo sapiens |
| 3 | The impact of the recommended first-line treatment with metformin on C-reactive protein (CRP) levels in patients with polycystic ovary syndrome (PCOS) is still controversial. | Metformin | C-reactive protein | Homo sapiens |
| 4 | We conducted a meta-analysis of studies reporting the impact of metformin on serum CRP levels in women with PCOS. | Metformin | C-reactive protein | Homo sapiens |
| 5 | CRP levels significantly decreased after metformin treatment (WMD = -1.23mg/L, 95%CI: -1.65 to -0.81, I2 = 93% and P < 0.001 for heterogeneity). | Metformin | C-reactive protein | Homo sapiens |
| 6 | Interestingly, the degree of decreased CRP levels was not depended on metformin dosage, but more significantly in patients treated beyond 6 months (WMD>=6months = -1.47mg/L vs. WMD<6months = -0.94 mg/L). | Metformin | C-reactive protein | Homo sapiens |
| 7 | Therefore, metformin shows the potential effects on CRP levels in women with PCOS. | Metformin | C-reactive protein | Homo sapiens |
| 8 | However, considering the very low quality of evidence for the analysis, the effect of metformin on CRP levels are still very uncertain, and large-scale randomized-controlled study is needed to ascertain the long-term effects of metformin in PCOS. | Metformin | C-reactive protein | Homo sapiens |