Title : Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH.

Pub. Date : 2017 Jun

PMID : 28404639






2 Functional Relationships(s)
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1 When HepG2 cells were exposed to LDL cholesterol, they developed cholesterol crystals in LD membranes, which caused activation of THP1 cells (macrophages) grown in coculture; upregulation of TNF-alpha, NLRP3, and interleukin 1beta (IL1beta) mRNA; and secretion of IL-1beta. Cholesterol tumor necrosis factor Homo sapiens
2 When HepG2 cells were exposed to LDL cholesterol, they developed cholesterol crystals in LD membranes, which caused activation of THP1 cells (macrophages) grown in coculture; upregulation of TNF-alpha, NLRP3, and interleukin 1beta (IL1beta) mRNA; and secretion of IL-1beta. Cholesterol tumor necrosis factor Homo sapiens