Title : Protein phosphatase 2C is responsible for VP-induced dephosphorylation of AQP2 serine 261.

Pub. Date : 2017 Aug 1

PMID : 28381458






2 Functional Relationships(s)
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1 Sanguinarine, a specific protein phosphatase (PP) 2C inhibitor, but not inhibitors of PP1, PP2A (okadaic acid), or PP2B (cyclosporine), abolished VP-induced S261 dephosphorylation. sanguinarine arginine vasopressin Homo sapiens
2 We also found that sanguinarine abolished VP-induced S261 dephosphorylation in cells expressing mutated AQP2 S256A, suggesting that the phosphorylation state of S261 is independent of S256. sanguinarine arginine vasopressin Homo sapiens