Title : The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells.

Pub. Date : 2017 Apr 4

PMID : 28377614






2 Functional Relationships(s)
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1 Moreover, pharmacological inhibition of the chaperone activity of Hsp90 and Hsp70 and of the peptidyl-prolyl cis/trans isomerase (PPIase) activity of Cyps and FKBPs protected cells from intoxication with diphtheria toxin and inhibited the pH-dependent trans-membrane transport of DTA into the cytosol. deoxythymidylyl-3'-5'-deoxyadenylate FKBP prolyl isomerase 4 Homo sapiens
2 Moreover, pharmacological inhibition of the chaperone activity of Hsp90 and Hsp70 and of the peptidyl-prolyl cis/trans isomerase (PPIase) activity of Cyps and FKBPs protected cells from intoxication with diphtheria toxin and inhibited the pH-dependent trans-membrane transport of DTA into the cytosol. deoxythymidylyl-3'-5'-deoxyadenylate FKBP prolyl isomerase 4 Homo sapiens