Pub. Date : 2017 Jun
PMID : 28376279
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Western blot analysis revealed that quercetin significantly induced the activation of two major cell survival kinases, protein kinase D1 (PKD1) and Akt in MN9D dopaminergic neuronal cells. | Quercetin | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Furthermore, pharmacological inhibition or siRNA knockdown of PKD1 blocked the activation of Akt, suggesting that PKD1 acts as an upstream regulator of Akt in quercetin-mediated neuroprotective signaling. | Quercetin | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Furthermore, pharmacological inhibition or siRNA knockdown of PKD1 blocked the activation of Akt, suggesting that PKD1 acts as an upstream regulator of Akt in quercetin-mediated neuroprotective signaling. | Quercetin | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | Together, our findings demonstrate that quercetin activates the PKD1-Akt cell survival signaling axis and suggest that further exploration of quercetin as a promising neuroprotective agent for treating PD may offer clinical benefits. | Quercetin | thymoma viral proto-oncogene 1 | Mus musculus |
| 5 | Together, our findings demonstrate that quercetin activates the PKD1-Akt cell survival signaling axis and suggest that further exploration of quercetin as a promising neuroprotective agent for treating PD may offer clinical benefits. | Quercetin | thymoma viral proto-oncogene 1 | Mus musculus |