Pub. Date : 2017 Jun 1
PMID : 28369648
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P450 enzymes metabolize chlorpyrifos to chlorpyrifos-oxon, which is then metabolized primarily to 3, 5, 6-trichloropyridinol in addition to diethylphosphate and diethylthiophosphate. | Chlorpyrifos | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | The P450 inhibitor SKF525A partly negated the protective effect of astrocytes, allowing reduction in branch points with chlorpyrifos (10 muM). | Chlorpyrifos | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | Thus, the scalable and defined astrocyte-neuron cocultures model that we established here has potentially identified a role for P450 enzymes in astrocytic neuroprotection against chlorpyrifos and provides a novel model for addressing DNT in a more accurate multicellular environment. | Chlorpyrifos | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |