Pub. Date : 2017 Mar
PMID : 28358927
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | For example, AQP2 in the human-infectious African trypanosome, Trypanosoma brucei gambiense, is responsible for melarsoprol and pentamidine-uptake, and melarsoprol treatment-failure has been found to be due to AQP2-defects in these parasites. | Melarsoprol | aquaporin 2 | Homo sapiens |
| 2 | For example, AQP2 in the human-infectious African trypanosome, Trypanosoma brucei gambiense, is responsible for melarsoprol and pentamidine-uptake, and melarsoprol treatment-failure has been found to be due to AQP2-defects in these parasites. | Melarsoprol | aquaporin 2 | Homo sapiens |
| 3 | Consistent with these findings, AQP2-defective, melarsoprol-resistant clinical isolates were sensitive to the TAO inhibitors, SHAM, propyl gallate and ascofuranone, relative to melarsoprol-sensitive reference strains. | Melarsoprol | aquaporin 2 | Homo sapiens |