Title : Caveolin-1-mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype.

Pub. Date : 2017 Mar 28

PMID : 28351945






4 Functional Relationships(s)
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1 The plasma membrane sodium-vitamin C cotransporter 2 (SVCT2) is the primary mediator of vitamin C uptake in neurons. Ascorbic Acid solute carrier family 23 member 2 Homo sapiens
2 SVCT2 specifically transports ascorbate, the reduced form of vitamin C, which acts as a reducing agent. Ascorbic Acid solute carrier family 23 member 2 Homo sapiens
3 SVCT2 specifically transports ascorbate, the reduced form of vitamin C, which acts as a reducing agent. Ascorbic Acid solute carrier family 23 member 2 Homo sapiens
4 We demonstrated that ascorbate uptake through SVCT2 was critical for the homeostasis of microglia, the resident myeloid cells of the CNS that are essential for proper functioning of the nervous tissue. Ascorbic Acid solute carrier family 23 member 2 Homo sapiens