Pub. Date : 2017 May
PMID : 28351890
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Meanwhile, reactive oxygen species and inactivation of mTOR were shown to be involved in autophagy initiation in SIRPalphaD1-Fc-treated cells, indicating a probable mechanism for autophagy activation after targeting CD47 by SIRPalphaD1-Fc. | Reactive Oxygen Species | CD47 molecule | Homo sapiens |
| 2 | In addition, simultaneously targeting both CD47 and autophagy in NSCLC xenograft models elicited enhanced antitumor effects, with recruitment of macrophages, activated caspase-3, and overproduction of ROS at the tumor site. | Reactive Oxygen Species | CD47 molecule | Homo sapiens |