Title : Upregulation of miR-137 reverses sorafenib resistance and cancer-initiating cell phenotypes by degrading ANT2 in hepatocellular carcinoma.

Pub. Date : 2017 Apr

PMID : 28350139






6 Functional Relationships(s)
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1 In the present study, we found that adenine nucleotide translocator 2 (ANT2) was upregulated in sorafenib-resistant HCC Huh7 cells (Huh7-R) and its overexpression promoted sorafenib resistance. Sorafenib MIR7-3 host gene Homo sapiens
2 In the present study, we found that adenine nucleotide translocator 2 (ANT2) was upregulated in sorafenib-resistant HCC Huh7 cells (Huh7-R) and its overexpression promoted sorafenib resistance. Sorafenib MIR7-3 host gene Homo sapiens
3 In the present study, we found that adenine nucleotide translocator 2 (ANT2) was upregulated in sorafenib-resistant HCC Huh7 cells (Huh7-R) and its overexpression promoted sorafenib resistance. Sorafenib MIR7-3 host gene Homo sapiens
4 miR-137 was downregulated in the Huh7-R cells, compared with that in the Huh7 cells and its restoration reversed sorafenib resistance in the Huh7-R cells. Sorafenib MIR7-3 host gene Homo sapiens
5 miR-137 was downregulated in the Huh7-R cells, compared with that in the Huh7 cells and its restoration reversed sorafenib resistance in the Huh7-R cells. Sorafenib MIR7-3 host gene Homo sapiens
6 miR-137 was downregulated in the Huh7-R cells, compared with that in the Huh7 cells and its restoration reversed sorafenib resistance in the Huh7-R cells. Sorafenib MIR7-3 host gene Homo sapiens