Pub. Date : 2017 Feb 1
PMID : 28345838
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The excision repair cross-complementation 1(ERCC1) enzyme plays an essential role in the nucleotide excision repair pathway, removing platinum-induced DNAadducts and contributing to cisplatin resistance. | Cisplatin | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |
| 2 | We hypothesized that assigning cisplatin based on pretreatment ERCC1 expressionwould improve response and survival. | Cisplatin | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |
| 3 | Positive ERCC1 expressionwas associated with short PFS (median, 5 months vs. 7 months; P = 0.043), short OS (median, 9 months vs. 11 months;P = 0.033) and poor response to cisplatin based chemotherapy (P = 0.046). | Cisplatin | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |