Title : GPER blockers as Nox downregulators: A new drug class to target chronic non-communicable diseases.

Pub. Date : 2018 Feb

PMID : 28343901






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cardiovascular diseases are characterized by increased production of reactive oxygen species (ROS) by NAPDH oxidase 1 (Nox1) and additional Nox isoforms among other sources. Reactive Oxygen Species NADPH oxidase 1 Homo sapiens
2 Cardiovascular diseases are characterized by increased production of reactive oxygen species (ROS) by NAPDH oxidase 1 (Nox1) and additional Nox isoforms among other sources. Reactive Oxygen Species NADPH oxidase 1 Homo sapiens
3 Cardiovascular diseases are characterized by increased production of reactive oxygen species (ROS) by NAPDH oxidase 1 (Nox1) and additional Nox isoforms among other sources. Reactive Oxygen Species NADPH oxidase 1 Homo sapiens
4 Cardiovascular diseases are characterized by increased production of reactive oxygen species (ROS) by NAPDH oxidase 1 (Nox1) and additional Nox isoforms among other sources. Reactive Oxygen Species NADPH oxidase 1 Homo sapiens
5 However, GPER also has constitutive activity, e.g. in the absence of specific agonists, that was recently shown to promote hypertension and aging-induced tissue damage by promoting Nox1-derived production of ROS. Reactive Oxygen Species NADPH oxidase 1 Homo sapiens