Title : Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway.

Pub. Date : 2017 May 19

PMID : 28341741






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 LPS, a TLR4 ligand, induces macrophages to generate prostaglandin E2 (PGE2) through inducible COX-2 and microsomal PGE2 synthase 1 (mPGES-1) (1). Dinoprostone prostaglandin E synthase Mus musculus
2 LPS, a TLR4 ligand, induces macrophages to generate prostaglandin E2 (PGE2) through inducible COX-2 and microsomal PGE2 synthase 1 (mPGES-1) (1). Dinoprostone prostaglandin E synthase Mus musculus
3 The ubiquitous induction of mPGES-1-dependent PGE2 may be crucial for innate immune system activation during various IL-33 driven pathologic disorders. Dinoprostone prostaglandin E synthase Mus musculus