Title : The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D.

Pub. Date : 2017 Jun

PMID : 28341201






1 Functional Relationships(s)
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1 Thus, the neuroprotective efficacy of KU-55933, a potent inhibitor of ATM, against cell damage evoked by oxidative stress (hydrogen peroxide, H2O2) has been studied in human neuroblastoma SH-SY5Y cells and compared with the efficacy of this agent in models of doxorubicin (Dox)- and staurosporine (St)-evoked cell death. 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one ATM serine/threonine kinase Homo sapiens