Title : Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway.

Pub. Date : 2017 Jun 1

PMID : 28339691






1 Functional Relationships(s)
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1 Z-guggulsterone (10, 30 mg/kg) administration prevented the reductions in brain-derived neurotrophic factor protein expression levels as well as the phosphorylation levels of cAMP response element binding protein, extracellular signal-regulated kinase 1/2, and protein kinase B in the hippocampus and cortex induced by chronic unpredictable stress. pregna-4,17-diene-3,16-dione mitogen-activated protein kinase 3 Mus musculus