Pub. Date : 2017 Jun 1
PMID : 28333280
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SUMMARY ANSWER: hCG signaling in ESCs activates the extracellular signal-regulated protein kinases 1 and 2 (Erk1/2) pathway through exchange protein activated by cyclic AMP (cAMP) (Epac) and transiently increases progesterone receptor (PR) transcript and protein expression and its transcriptional function. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 2 | SUMMARY ANSWER: hCG signaling in ESCs activates the extracellular signal-regulated protein kinases 1 and 2 (Erk1/2) pathway through exchange protein activated by cyclic AMP (cAMP) (Epac) and transiently increases progesterone receptor (PR) transcript and protein expression and its transcriptional function. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 3 | hCG signals through cAMP/protein kinase A (PKA) in gonadal cells, but in endometrial epithelial cells, hCG induces Erk1/2 activation independent of the cAMP/PKA pathway. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 4 | MAIN RESULTS AND THE ROLE OF CHANCE: Addition of hCG to ESCs in vitro induced the phosphorylation of Erk1/2 through cAMP accumulation. | Cyclic AMP | hypertrichosis 2 (generalised, congenital) | Homo sapiens |