Pub. Date : 2017 Nov
PMID : 28331226
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL. | givinostat | cytokine receptor like factor 2 | Homo sapiens |
| 2 | Here, we found that givinostat inhibited proliferation and induced apoptosis of BCP-ALL CRLF2-rearranged cell lines, positive for exon 16 JAK2 mutations. | givinostat | cytokine receptor like factor 2 | Homo sapiens |
| 3 | Lastly, the selective killing of cancer cells by givinostat may allow the design of reduced intensity regimens in CRLF2-rearranged Down syndrome-associated BCP-ALL patients with an overall benefit in terms of both toxicity and related complications. | givinostat | cytokine receptor like factor 2 | Homo sapiens |