Pub. Date : 1988 Jan 19
PMID : 2832191
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evidence for a differential interaction of buprenorphine with opiate receptor subtypes controlling prolactin secretion. | Buprenorphine | prolactin | Homo sapiens |
| 2 | We studied the effects of various doses of the opiate derivative buprenorphine on serum prolactin levels and whether these effects could be counteracted by pretreatment with the opiate receptor blocker naloxone. | Buprenorphine | prolactin | Homo sapiens |
| 3 | The administration of increasing doses of buprenorphine exerted a dual effect on serum prolactin levels. | Buprenorphine | prolactin | Homo sapiens |
| 4 | These data are compatible with the hypothesis that buprenorphine could interfere with two different, but inter-dependent receptors: at low doses the oripavine derivative could act at one receptor site to cause an increase of serum prolactin, whereas at higher doses it could interact with a second site of lower affinity that is responsible for the inhibition of prolactin secretion. | Buprenorphine | prolactin | Homo sapiens |
| 5 | These data are compatible with the hypothesis that buprenorphine could interfere with two different, but inter-dependent receptors: at low doses the oripavine derivative could act at one receptor site to cause an increase of serum prolactin, whereas at higher doses it could interact with a second site of lower affinity that is responsible for the inhibition of prolactin secretion. | Buprenorphine | prolactin | Homo sapiens |