Title : The Sigma-1 Receptor-A Therapeutic Target for the Treatment of ALS?

Pub. Date : 2017

PMID : 28315276






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The S1R colocalizes in C-terminals with Indole(ethyl)amine-N-methyl transferase (INMT ), the enzyme that produces the S1R agonist , N,N"- dimethyltryptamine (DMT). N,N-Dimethyltryptamine indolethylamine N-methyltransferase Mus musculus
2 The S1R colocalizes in C-terminals with Indole(ethyl)amine-N-methyl transferase (INMT ), the enzyme that produces the S1R agonist , N,N"- dimethyltryptamine (DMT). N,N-Dimethyltryptamine indolethylamine N-methyltransferase Mus musculus
3 INMT methylation can additionally neutralize endogenous toxic sulfur and selenium derivatives thus providing functional synergism with DMT to reduce oxidative stress in motor neurons . N,N-Dimethyltryptamine indolethylamine N-methyltransferase Mus musculus