Title : Endothelium-derived relaxant factor inhibits platelet activation.

Pub. Date : 1987 Nov

PMID : 2830546






2 Functional Relationships(s)
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Protein Name
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1 EDRF had no effect on the intracellular free calcium concentration (Cai2+, measured with the fluorescent indicator indo-1) of resting washed human platelets but significantly attenuated the thrombin-induced rise of Cai2+ from 896 +/- 99 (SEM) to 509 +/- 48 nmol/l. cai2+ alpha hemoglobin stabilizing protein Homo sapiens
2 EDRF had no effect on Cai2+, cyclic GMP or aggregation after a 3 min storage interval, but superoxide dismutase (shown to increase stability of the labile factor) significantly augmented the EDRF effects on Cai2+. cai2+ alpha hemoglobin stabilizing protein Homo sapiens