Title : Oligo(ethylene glycol)-modified β-cyclodextrin-based polyrotaxanes for simultaneously modulating solubility and cellular internalization efficiency.

Pub. Date : 2017 Jul - Aug

PMID : 28299982






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1 We developed stimuli-labile polyrotaxanes (PRXs) composed of beta-cyclodextrin (beta-CD), Pluronic as an axle polymer, and acid-cleavable N-triphenylmethyl groups as bulky stopper molecules, and found that the PRXs are potent therapeutics for Niemann-Pick type C disease, because the PRX can effectively reduce intracellular cholesterol through the intracellular release of threaded beta-CDs. Rotaxanes beta-carotene oxygenase 1 Mus musculus