Title : The Induction of Pro-IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production.

Pub. Date : 2017 May 1

PMID : 28298525






2 Functional Relationships(s)
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1 We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha. Dinoprostone interleukin 1 beta Mus musculus
2 We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha. Dinoprostone interleukin 1 beta Mus musculus