Pub. Date : 2017 May 1
PMID : 28298525
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Induction of Pro-IL-1beta by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 2 | PGE2 has been shown to increase the transcription of pro-IL-1beta. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 3 | However, recently it has been demonstrated that PGE2 can block the maturation of IL-1beta by inhibiting the NLRP3 inflammasome in macrophages. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 4 | These apparently conflicting results have led us to reexamine the effect of PGE2 on IL-1beta production. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 5 | We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 6 | We also examined the effect of endogenously produced PGE2 on IL-1beta production. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 7 | By blocking PGE2 production with indomethacin, we made a striking finding that endogenous PGE2 is essential for LPS-induced pro-IL-1beta production, suggesting a positive feedback loop. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 8 | By blocking PGE2 production with indomethacin, we made a striking finding that endogenous PGE2 is essential for LPS-induced pro-IL-1beta production, suggesting a positive feedback loop. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 9 | In primary human monocytes, where LPS alone is sufficient to induce mature IL-1beta, PGE2 boosted LPS-induced IL-1beta production. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 10 | In primary human monocytes, where LPS alone is sufficient to induce mature IL-1beta, PGE2 boosted LPS-induced IL-1beta production. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 11 | Because PGE2 mediates the pyrogenic effect of IL-1beta, these effects might be especially relevant for the role of monocytes in the induction of fever. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 12 | A positive feedback loop from IL-1beta and back to PGE2, which itself is induced by IL-1beta, is likely to be operating. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 13 | A positive feedback loop from IL-1beta and back to PGE2, which itself is induced by IL-1beta, is likely to be operating. | Dinoprostone | interleukin 1 beta | Homo sapiens |