Title : Establishment of patient-derived gastric cancer xenografts: a useful tool for preclinical evaluation of targeted therapies involving alterations in HER-2, MET and FGFR2 signaling pathways.

Pub. Date : 2017 Mar 14

PMID : 28292264






2 Functional Relationships(s)
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1 Crizotinib and AZD4547 exerted marked antitumor effects exclusively in PDX models with cMet (G30,G31) and FGFR2(G03) amplification. Crizotinib fibroblast growth factor receptor 2 Homo sapiens
2 Interestingly, synergistic antitumor activity was observed in G03 (FGFR2-amplifed and cMet non-amplified but IHC [2+]) with simultaneous treatment with Crizotinib and ADZ4547 at day 30 post-treatment. Crizotinib fibroblast growth factor receptor 2 Homo sapiens