Title : Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain.

Pub. Date : 2018 Jan

PMID : 28290528






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CYP2A6, the primary hepatic nicotine metabolism gene, is robustly associated with cigarette consumption but other enzymes contribute to nicotine metabolism. Nicotine cytochrome P450 family 2 subfamily A member 6 Homo sapiens
2 CYP2A6, the primary hepatic nicotine metabolism gene, is robustly associated with cigarette consumption but other enzymes contribute to nicotine metabolism. Nicotine cytochrome P450 family 2 subfamily A member 6 Homo sapiens
3 The polymorphism rs2266780 (E308G) was associated with N-oxidation of both orally administered and ad libitum smoked nicotine (P<=3.3 x 10-5 controlling for CYP2A6 genotype). Nicotine cytochrome P450 family 2 subfamily A member 6 Homo sapiens