Pub. Date : 2018 Mar
PMID : 28287856
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CS-0777, a candidate compound for autoimmune diseases, becomes phosphorylated active metabolite, M1, by fructosamine 3-kinase (FN3K), FN3K-related protein (FN3K-RP); and M1 is reverted back to CS-0777 by alkaline phosphatase (ALP) in the body. | Cesium | fructosamine 3 kinase | Homo sapiens |
| 2 | CS-0777, a candidate compound for autoimmune diseases, becomes phosphorylated active metabolite, M1, by fructosamine 3-kinase (FN3K), FN3K-related protein (FN3K-RP); and M1 is reverted back to CS-0777 by alkaline phosphatase (ALP) in the body. | Cesium | fructosamine 3 kinase | Homo sapiens |
| 3 | CS-0777, a candidate compound for autoimmune diseases, becomes phosphorylated active metabolite, M1, by fructosamine 3-kinase (FN3K), FN3K-related protein (FN3K-RP); and M1 is reverted back to CS-0777 by alkaline phosphatase (ALP) in the body. | Cesium | fructosamine 3 kinase | Homo sapiens |
| 4 | We performed enzyme kinetic analysis of phosphorylation of CS-0777 by FN3K, FN3K-RP, human erythrocytes and human platelets; and dephosphorylation of M1 by various ALP isozymes and human liver, kidney, lung and small intestine microsomes. | Cesium | fructosamine 3 kinase | Homo sapiens |
| 5 | The Michaelis constants of human FN3K, FN3K-RP and erythrocytes for CS-0777 phosphorylation were in the range from 498 muM to 1060 muM. | Cesium | fructosamine 3 kinase | Homo sapiens |
| 6 | FN3K inhibitor, 1-deoxy-1-morpholinofructose, suppressed only about 20% of CS-0777 phosphorylation activity in human erythrocyte lysate. | Cesium | fructosamine 3 kinase | Homo sapiens |