Title : GPER modulators: Opportunity Nox on the heels of a class Akt.

Pub. Date : 2018 Feb

PMID : 28285016






3 Functional Relationships(s)
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1 This viewpoint changed recently with the discovery that GPER is associated with aging, particularly that of the cardiovascular system, where the GPER antagonist G36 reduced hypertension and GPER deficiency prevented cardiac fibrosis and vascular dysfunction with age, through the downregulation of Nox1 and as a consequence superoxide production. Superoxides G protein-coupled estrogen receptor 1 Homo sapiens
2 This viewpoint changed recently with the discovery that GPER is associated with aging, particularly that of the cardiovascular system, where the GPER antagonist G36 reduced hypertension and GPER deficiency prevented cardiac fibrosis and vascular dysfunction with age, through the downregulation of Nox1 and as a consequence superoxide production. Superoxides G protein-coupled estrogen receptor 1 Homo sapiens
3 This viewpoint changed recently with the discovery that GPER is associated with aging, particularly that of the cardiovascular system, where the GPER antagonist G36 reduced hypertension and GPER deficiency prevented cardiac fibrosis and vascular dysfunction with age, through the downregulation of Nox1 and as a consequence superoxide production. Superoxides G protein-coupled estrogen receptor 1 Homo sapiens