Title : New Insights in Thrombin Inhibition Structure-Activity Relationships by Characterization of Octadecasaccharides from Low Molecular Weight Heparin.

Pub. Date : 2017 Mar 8

PMID : 28282887






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Low Molecular Weight Heparins (LMWH) are complex anticoagulant drugs that mainly inhibit the blood coagulation cascade through indirect interaction with antithrombin. Heparin, Low-Molecular-Weight serpin family C member 1 Homo sapiens
2 In fact, a minimal chain length of 18 saccharides units, including an antithrombin (AT) binding pentasaccharide, is mandatory to form the active ternary complex for LMWH obtained by alkaline beta-elimination (e.g., enoxaparin). Heparin, Low-Molecular-Weight serpin family C member 1 Homo sapiens