Title : Altered expression of a metformin-mediated radiation response in SA-NH and FSa tumor cells treated under in vitro and in vivo growth conditions.

Pub. Date : 2017 Jul

PMID : 28281393






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 RESULTS: Both metformin and rotenone protected SA-NH (p < .001) while sensitizing FSa (p < .001) to 4 Gy. Metformin RIKEN cDNA 4932438A13 gene Mus musculus
2 Metformin was also directly toxic to FSa cells (p = .002). Metformin RIKEN cDNA 4932438A13 gene Mus musculus
3 In contrast, in vivo metformin (250 mg/kg) sensitized both SA-NH (9-day growth delay, p < .05) and FSa (4-day growth delay, p < .05) tumors if administered 1 h before irradiation. Metformin RIKEN cDNA 4932438A13 gene Mus musculus