Title : Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.

Pub. Date : 2017 Mar 9

PMID : 28276480






2 Functional Relationships(s)
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1 We demonstrate that mocetinostat (MGCD0103), a selective HDAC1/HDAC2 inhibitor, is a potent Hh inhibitor and that its effect is linked to Gli1 acetylation at K518. mocetinostat histone deacetylase 1 Mus musculus
2 We demonstrate that mocetinostat (MGCD0103), a selective HDAC1/HDAC2 inhibitor, is a potent Hh inhibitor and that its effect is linked to Gli1 acetylation at K518. mocetinostat histone deacetylase 1 Mus musculus