Pub. Date : 2017 Mar 7
PMID : 28270124
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5. | Cyproterone Acetate | TNF superfamily member 10 | Homo sapiens |
| 2 | Herein the effects of cyproterone acetate, an antiandrogen steroid, on the TRAIL-induced apoptosis of androgen receptor-negative prostate cancer cells are reported. | Cyproterone Acetate | TNF superfamily member 10 | Homo sapiens |
| 3 | RESULTS: Cyproterone acetate but not AR antagonist bicalutamide dramatically increased the susceptibility of androgen receptor-negative human prostate cancer PC-3 and DU145 cells to TRAIL-induced apoptosis but no effects on immortalized human prostate stromal PS30 cells and human embryonic kidney HEK293 cells. | Cyproterone Acetate | TNF superfamily member 10 | Homo sapiens |
| 4 | Further investigation of the TRAIL-induced apoptosis pathway revealed that cyproterone acetate exerted its effect by selectively increasing death receptor 5 (DR5) mRNA and protein expression. | Cyproterone Acetate | TNF superfamily member 10 | Homo sapiens |
| 5 | CONCLUSIONS: Our study shows a novel effect of cyproterone acetate on apoptosis pathways in prostate cancer cells and raises the possibility that a combination of TRAIL with cyproterone acetate could be a promising strategy for treating castration-resistant prostate cancer. | Cyproterone Acetate | TNF superfamily member 10 | Homo sapiens |