Pub. Date : 2017 Jun 1
PMID : 28267592
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | sFRP4 signalling of apoptosis and angiostasis uses nitric oxide-cGMP-permeability axis of endothelium. | Cyclic GMP | secreted frizzled related protein 4 | Homo sapiens |
| 2 | Results demonstrate that sFRP4 causes endothelial dysfunction by suppressing NO-cGMP signaling and elevating corresponding ROS levels. | Cyclic GMP | secreted frizzled related protein 4 | Homo sapiens |
| 3 | In conclusion, the current study reports that sFRP4-mediated anti-angiogenesis occurs as a result of impaired NO-cGMP signaling which in turn allow for elevation of redox levels and promotion of apoptosis of endothelial cells. | Cyclic GMP | secreted frizzled related protein 4 | Homo sapiens |