Pub. Date : 2017 May
PMID : 28266877
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therefore, elimination of parent compound via glucuronidation in a metabolic active cell is controlled by two driving forces: the formation of glucuronides by UGT enzymes and the (polarized) excretion of these glucuronides by efflux transporters located on the cell surfaces in various drug disposition organs. | Glucuronides | UDP glucuronosyltransferase family 1 member A complex locus | Homo sapiens |
| 2 | Therefore, elimination of parent compound via glucuronidation in a metabolic active cell is controlled by two driving forces: the formation of glucuronides by UGT enzymes and the (polarized) excretion of these glucuronides by efflux transporters located on the cell surfaces in various drug disposition organs. | Glucuronides | UDP glucuronosyltransferase family 1 member A complex locus | Homo sapiens |
| 3 | Taken together, these recent research advances indicate that although UGT determines the rate and extent of glucuronide generation, the efflux and uptake transporters determine the distribution of these glucuronides into blood and then to various organs for elimination. | Glucuronides | UDP glucuronosyltransferase family 1 member A complex locus | Homo sapiens |
| 4 | Taken together, these recent research advances indicate that although UGT determines the rate and extent of glucuronide generation, the efflux and uptake transporters determine the distribution of these glucuronides into blood and then to various organs for elimination. | Glucuronides | UDP glucuronosyltransferase family 1 member A complex locus | Homo sapiens |