Title : Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance.

Pub. Date : 2017 Apr

PMID : 28260069






3 Functional Relationships(s)
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1 ERCC1 expression in this cell line is high and contributes to its resistance to cisplatin. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
2 Suppression of ERCC1 decreased XWLC05 proliferation in vitro (IC50 of cisplatin 1.34 microM for shRNA-infected cells vs. 4.54 microM for control cells) and increased the apoptotic rate after treatment with cisplatin (81.2% shRNA cells vs. 58% control cells, P<0.05). Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
3 Suppression of ERCC1 decreased XWLC05 proliferation in vitro (IC50 of cisplatin 1.34 microM for shRNA-infected cells vs. 4.54 microM for control cells) and increased the apoptotic rate after treatment with cisplatin (81.2% shRNA cells vs. 58% control cells, P<0.05). Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens