Title : The SMX DNA Repair Tri-nuclease.

Pub. Date : 2017 Mar 2

PMID : 28257701






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Within SMX, SLX4 co-ordinates the SLX1 and MUS81-EME1 nucleases for Holliday junction resolution, in a reaction stimulated by XPF-ERCC1. Sulfamethoxazole MUS81 structure-specific endonuclease subunit Homo sapiens
2 SMX formation activates MUS81-EME1 for replication fork and flap structure cleavage by relaxing substrate specificity. Sulfamethoxazole MUS81 structure-specific endonuclease subunit Homo sapiens