Title : Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects.

Pub. Date : 2017 Apr 3

PMID : 28240606






2 Functional Relationships(s)
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Protein Name
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1 In cultured cells, treatment with sunitinib and erlotinib, approved anticancer drugs that inhibit AAK1 or GAK activity, or with more selective compounds inhibited intracellular trafficking of HCV and multiple unrelated RNA viruses with a high barrier to resistance. Erlotinib Hydrochloride AP2 associated kinase 1 Homo sapiens
2 We validated sunitinib- and erlotinib-mediated inhibition of AAK1 and GAK activity as an important mechanism of antiviral action. Erlotinib Hydrochloride AP2 associated kinase 1 Homo sapiens