Title : Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway.

Pub. Date : 2017

PMID : 28234968






3 Functional Relationships(s)
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1 We hypothesized that trichostatin A (TSA), a HDAC inhibitor, can reduce MV-augmented bleomycin-induced EMT by inhibiting the HDAC4 and Akt pathways. trichostatin A histone deacetylase 4 Mus musculus
2 We hypothesized that trichostatin A (TSA), a HDAC inhibitor, can reduce MV-augmented bleomycin-induced EMT by inhibiting the HDAC4 and Akt pathways. trichostatin A histone deacetylase 4 Mus musculus
3 CONCLUSIONS: Our data indicate that TSA treatment attenuates high-VT MV-augmented EMT after bleomycin-induced ALI, in part by inhibiting the HDAC4 and Akt pathways. trichostatin A histone deacetylase 4 Mus musculus