Title : Vascular smooth muscle cell peroxisome proliferator-activated receptor γ protects against endothelin-1-induced oxidative stress and inflammation.

Pub. Date : 2017 Jul

PMID : 28234672






2 Functional Relationships(s)
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1 N(omega)-Nitro-L-arginine methyl ester abrogated relaxation responses, and the Ednra/Ednrb mRNA ratio was decreased in eET-1/smPpargamma-/-, which could indicate that nitric oxide production was enhanced by ET-1 stimulation of endothelin type B receptors. Nitric Oxide endothelin 1 Mus musculus
2 Paradoxically, ET-1 overexpression preserved endothelial function in smPpargamma-/- mice, presumably by enhancing nitric oxide through stimulation of endothelin type B receptors. Nitric Oxide endothelin 1 Mus musculus