Title : Homocysteine and all-cause mortality in hypertensive adults without pre-existing cardiovascular conditions: Effect modification by MTHFR C677T polymorphism.

Pub. Date : 2017 Feb

PMID : 28225483






3 Functional Relationships(s)
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1 Potential effect modification by the MTHFR genotype on the relationship between tHcy and all-cause mortality was tested. thcy methylenetetrahydrofolate reductase Homo sapiens
2 Whereas the MTHFR genotype alone had little effect on mortality, it significantly modified the tHcy-mortality association, which was much stronger in the CC/CT genotype than in the TT genotype (P for interaction < 0.05). thcy methylenetetrahydrofolate reductase Homo sapiens
3 CONCLUSIONS: Among Chinese hypertensive patients without cardiovascular comorbidities, elevated tHcy was a significant risk marker for death from all causes, and the association was subject to effect modification by MTHFR genotypes. thcy methylenetetrahydrofolate reductase Homo sapiens