Pub. Date : 2017 Apr 15
PMID : 28219807
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It was detected that specifically MAPK pathway was activated in MG63 stimulated by Sr. To verify the role of Setd2 in bone formation in the presence of SrCl2, Setd2 was knocked-down and overexpressed in MG63 with/without SrCl2 stimulation. | strontium chloride | SET domain containing 2, histone lysine methyltransferase | Rattus norvegicus |
| 2 | The result showed that Setd2 plays a positive role in osteoblast differentiation which was enhanced by SrCl2. | strontium chloride | SET domain containing 2, histone lysine methyltransferase | Rattus norvegicus |
| 3 | In vitro, the increased expression of Setd2 promoted osteoblastic differentiation of MG63 stimulated by SrCl2 in MAPK-dependent way, which activated ERK in turn leading to a positive feedback. | strontium chloride | SET domain containing 2, histone lysine methyltransferase | Rattus norvegicus |