Title : Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina.

Pub. Date : 2017 Feb 20

PMID : 28216676






2 Functional Relationships(s)
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1 Norgestrel upregulates fractalkine-CX3CR1 signaling in the rd10 retina, coinciding with photoreceptor survival. Norgestrel phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide Mus musculus
2 We show that Norgestrel-treated photoreceptor-like cells, 661Ws, and C57 explants modulate rd10 microglial activity in co-culture, resulting in increased photoreceptor survival. Norgestrel phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide Mus musculus