Pub. Date : 2017 Apr 14
PMID : 28213520
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus. | Cholesterol | potassium inwardly rectifying channel subfamily J member 3 L homeolog | Xenopus laevis |
| 2 | Yet, the effect of cholesterol on G protein-gated inwardly rectifying potassium (GIRK) channels expressed in the brain is unknown. | Cholesterol | potassium inwardly rectifying channel subfamily J member 3 L homeolog | Xenopus laevis |
| 3 | We also demonstrate that cholesterol plays a critical role in modulating neuronal GIRK currents. | Cholesterol | potassium inwardly rectifying channel subfamily J member 3 L homeolog | Xenopus laevis |
| 4 | In accordance, elevated currents upon cholesterol enrichment were also observed in Xenopus oocytes expressing GIRK2 channels, the primary GIRK subunit expressed in the brain. | Cholesterol | potassium inwardly rectifying channel subfamily J member 3 L homeolog | Xenopus laevis |
| 5 | These findings establish that cholesterol plays a critical role in modulating GIRK activity in the brain. | Cholesterol | potassium inwardly rectifying channel subfamily J member 3 L homeolog | Xenopus laevis |
| 6 | Because up-regulation of GIRK function can reduce neuronal activity, our findings may lead to novel approaches for prevention and therapy of cholesterol-driven neurodegenerative disease. | Cholesterol | potassium inwardly rectifying channel subfamily J member 3 L homeolog | Xenopus laevis |