Title : Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.

Pub. Date : 2017 Apr 15

PMID : 28213091






1 Functional Relationships(s)
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1 Consistent with this heme accumulation, differential gene expression suggests that heme activated BACH1 and REV-ERBalpha/beta, causing induction of heme oxygenase 1 (Hmox1) and repression of fatty acid biosynthesis, respectively. Fatty Acids nuclear receptor subfamily 1, group D, member 1 Mus musculus