Pub. Date : 2017 Apr 1
PMID : 28202415
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therefore, we examined whether treatment with TNF-related apoptosis-inducing ligand (TRAIL) sensitizes MDA-MB-231 cells to apoptosis under Gln deprivation condition (TRAIL/Gln deprivation). | Glutamine | TNF superfamily member 10 | Homo sapiens |
| 2 | Therefore, we examined whether treatment with TNF-related apoptosis-inducing ligand (TRAIL) sensitizes MDA-MB-231 cells to apoptosis under Gln deprivation condition (TRAIL/Gln deprivation). | Glutamine | TNF superfamily member 10 | Homo sapiens |
| 3 | Therefore, we examined whether treatment with TNF-related apoptosis-inducing ligand (TRAIL) sensitizes MDA-MB-231 cells to apoptosis under Gln deprivation condition (TRAIL/Gln deprivation). | Glutamine | TNF superfamily member 10 | Homo sapiens |
| 4 | TRAIL/Gln deprivation, however, significantly increased growth inhibition and morphological shrinkage of MDA-MB-231 cells compared to those induced by treatment with either Gln deprivation or TRAIL alone. | Glutamine | TNF superfamily member 10 | Homo sapiens |
| 5 | TRAIL/Gln deprivation, however, significantly increased growth inhibition and morphological shrinkage of MDA-MB-231 cells compared to those induced by treatment with either Gln deprivation or TRAIL alone. | Glutamine | TNF superfamily member 10 | Homo sapiens |
| 6 | Moreover, TRAIL/Gln deprivation upregulated the apoptotic sub-G1 phase accompanied with a remarkable decrease of pro-caspase-3, pro-caspase-9, and anti-apoptotic xIAP, and Bcl-2. | Glutamine | TNF superfamily member 10 | Homo sapiens |
| 7 | Increased cleavage of PARP and pro-apoptotic Bid protein expression suggests that TRAIL/Gln deprivation triggers mitochondrion-mediated apoptosis in MDA-MB-231 cells. | Glutamine | TNF superfamily member 10 | Homo sapiens |
| 8 | Additionally, TRAIL/Gln deprivation upregulated the expression of endoplasmic reticulum (ER) stress markers such as ATF4 and phosphorylated eIF2alpha, thereby enhancing the C/EBP homologous protein (CHOP) protein level. | Glutamine | TNF superfamily member 10 | Homo sapiens |
| 9 | Accordingly, TRAIL/Gln deprivation enhanced the expression of death receptor 5 (DR5) and transient knockdown of DR5 completely restored TRAIL/Gln deprivation-mediated apoptosis. | Glutamine | TNF superfamily member 10 | Homo sapiens |
| 10 | Accordingly, TRAIL/Gln deprivation enhanced the expression of death receptor 5 (DR5) and transient knockdown of DR5 completely restored TRAIL/Gln deprivation-mediated apoptosis. | Glutamine | TNF superfamily member 10 | Homo sapiens |
| 11 | Taken together, our results suggest that Gln deprivation conditions can be used for the development of new therapies for TRAIL-resistant cancers. | Glutamine | TNF superfamily member 10 | Homo sapiens |