Title : Exposure to PM2.5 induces aberrant activation of NF-κB in human airway epithelial cells by downregulating miR-331 expression.

Pub. Date : 2017 Mar

PMID : 28192748






2 Functional Relationships(s)
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1 In addition, PM2.5 exposure significantly decreased miR-331 expression in B2B cells, which was abrogated by inhibition of ROS or phosphoinositide 3-kinase (PI3K)/Akt pathway. Reactive Oxygen Species microRNA 331 Homo sapiens
2 Therefore, PM2.5 exposure decreased miR-331 expression via the ROS/PI3K/Akt pathway, resulting in an increase in the IKK-beta expression and sustained NF-kappaB activation in human airway epithelial cells. Reactive Oxygen Species microRNA 331 Homo sapiens