Title : YPC-21661 and YPC-22026, novel small molecules, inhibit ZNF143 activity in vitro and in vivo.

Pub. Date : 2017 May

PMID : 28192620






1 Functional Relationships(s)
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1 In the present study, we identified a novel small molecule N-(5-bromo-2-methoxyphenyl)-3-(pyridine-3-yl) propiolamide (YPC-21661) that inhibited ZNF143 promoter activity and down-regulated the expression of the ZNF143-regulated genes, RAD51, PLK1, and Survivin, by inhibiting the binding of ZNF143 to DNA. n-(5-bromo-2-methoxyphenyl)-3-(pyridine-3-yl) propiolamide RAD51 recombinase Homo sapiens