Title : Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists.

Pub. Date : 2017 Mar 15

PMID : 28190654






2 Functional Relationships(s)
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1 Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists. benzimidazole nuclear receptor subfamily 1 group H member 4 Homo sapiens
2 We describe here a novel chemotype with substituted benzimidazole scaffold for nonsteroidal farnesoid X receptor (FXR) antagonists starting from the identification of a screening hit, BB-4. benzimidazole nuclear receptor subfamily 1 group H member 4 Homo sapiens